The DaRE Lab is interested in DNA and RNA editing, particularly in the context of cell identity. Although living cells have biological information hardwired into their genomes, this information can be naturally or artificially altered, either at the level of DNA where the changes can be permanent or at the level of RNA where the changes can be dynamic. We are focused on (1) developing and applying powerful new genome engineering technologies to understand cell fate decisions and (2) unraveling the functions and regulation of RNA editing in human development and diseases. Our research activities fall under the broad umbrella of systems and synthetic biology.
December 2017: Danny and Kean Hean are continuing in our lab for their final year projects (FYPs). Welcome again!
November 2017: Our undergraduate students from NTU have been awarded a Gold medal at iGEM for their outstanding research on developing and applying novel CRISPR-Cas technologies. Congratulations to the team!
October 2017: Our work on comprehensively mapping the RNA editing landscape and deciphering the complex regulation of editing in mammals has been published in Nature! Congratulations to Raghu, Ivy, and our many wonderful collaborators!
October 2017: Our new postdoc, Chai, joins us from MIT/ Stanford University. Welcome!
September 2017: Meng How gave an invited talk at the IBS-Nature Conference on Frontiers in Genome Engineering. We received interest in our CRISPR work!
September 2017: Liu Hao, Yirong, Joseph, Albert, and Lysia join our lab to pursue research under the URECA programme for outstanding undergraduate students. Welcome!
August 2017: Evelyn, Haumin, Yuanlong, and Ernest join our lab to pursue their final year projects (FYPs). Welcome!
August 2017: Heyun and Yu Lu join our lab to pursue their masters degrees in biomedical engineering. Welcome!
July 2017: Our new postdoc, Qixing, joins us from the National University of Singapore. Welcome!
July 2017: Our new postdoc, Richard, joins us from the Cancer Science Institute (CSI) in the National University of Singapore. Welcome!
June 2017: Our collaborative work with the Metabolic Engineering Research Laboratory (MERL) at A*STAR on engineering novel biosensors in yeast has been published in Bioresource Technology!
February 2017: Some earlier research done by Meng How when he was a postdoc at Stanford University has been published in Science!
November 2016: Meng How presented an invited seminar at the Division of Biomedical Engineering in Hong Kong University of Science and Technology (HKUST) on our RNA editing research. It was a great networking session with the faculty and students at HKUST!
November 2016: Meng How gave a talk at the Cell Symposium on Functional RNAs on our study of the regulation of RNA editing. We received positive feedback about our work!
October 2016: The NTU iGEM team led by Meng How has been awarded a Gold medal for their research on CRISPR-Cas. The team has also been awarded the prize for the Best Measurement Project as well as the prize for the Best Wiki (Overgrad). Additionally, they were nominated for the Best Basic Part prize and were commended during the Giant Jamboree for performing research that has high society impact. Congratulations to the team!
September 2016: Kelvin, Ignatius, Jaclyn, Hsin-Yueh, Danny, and Kar Ming join our lab to pursue research under the URECA programme for outstanding undergraduate students. Welcome!
August 2016: Shi Mun and Wang Fei join our lab to pursue their masters degrees in biomedical engineering. Welcome!
July 2016: Our work on engineering a fast chemical-inducible CRISPR-Cas9 system has been accepted by Nature Chemical Biology! Congratulations to Ivy and the rest of the team!
February 2016: Our new postdoc, Li Jia, joins us from the Chinese Academy of Sciences. Welcome!
January 2016: Our new postdoc, Yuanming, joins us from Shanghai Jiao Tong University. Welcome!